1 tablet contains 2.5 mg of active substance indapamideas well as additional substances: magnesium stearate, starch, talc, lactose, povidone.
The composition of the tablet shell: wax, macrogoltitanium dioxide, hydroxypropyl methylcellulose, glycerin, sodium lauryl sulfate, magnesium stearate.
Arifon is available in tablet form. The prolonged form of the drug Arifon Retard is available in capsules.
Antihypertensive drug, diuretic.
Pharmacodynamics and pharmacokinetics
The active component is indapamide. The drug has vasodilating effect.
According to its pharmacological mechanism of action, Arifon is similar to thiazide diuretics: the reabsorption of sodium ions in the cortical region in the Henle loop is disrupted.
The drug enhances the excretion of chloride ions, sodium in the urine, as well as magnesium and potassium. The drug selectively blocks “slow” calcium channels, reduces OPSS, increases the elasticity of arterial walls. Arifon does not affect the metabolism of carbohydrates, the lipid content in the blood, helps to reduce the size of the hypertrophied left ventricle.
The drug reduces the sensitivity of the walls of blood vessels to exposure norepinephrine, angiotensin-2, stimulates the production of prostacyclin, prostaglandinsreduces the production of stable, free oxygen radicals.
Prescribing high dosages does not affect the level of lowering blood pressure in proportion to diuresis. With regular use, a stable result is observed in the second week of therapy.
What are the pills from?
The medicine is prescribed for essential hypertension.
The medication is contraindicated in severe pathology of the renal system, with anuria, encephalopathy, hypokalemia, intolerance Indapamidewith diabetes with ketoacidosis (decompensated form), in acute violation of the blood supply to the brain, with galactosemialactose intolerance.
With pathology water-electrolyte metabolism, with hyponatremia, CHF, IHD, ascites, moderate renal failure, with breastfeeding, hyperparathyroidism, gout, elderly people, with gestation of pregnancy Arifon is prescribed with caution.
The severity of side effects is dose-dependent.
Digestive tract: epigastric pain diarrhea, constipation, dyspeptic disorders, nausea, dry mouth, gastralgiavomiting, impaired appetite.
Nervous system: nervousness, dizziness, headaches, asthenia, vertigo, drowsiness, asthenia, fatigue, agitation, irritability, muscle spasm, nervousness, malaise, lethargy, lethargy, depression, sleep disturbance.
Sensory organs: conjunctivitisvisual impairment.
Respiratory system: sinusitis, cough, pharyngitis, rhinitis.
The cardiovascular system: hypokalemia is reflected in the ECG, orthostatic hypotension, palpitations, arrhythmia.
Urinary system: polyuria, nocturia.
It is also possible the development of an allergic response, pain in the sternum, flu-like syndrome, back pain, infectious lesions, hyperglycemia, hyperuricemia, hypercalcemia, increased urea nitrogen in the plasma, hypercreatininemiahypochloremia, vasculitis, rash, itching, hives.
Arifon, instructions for use (Method and dosage)
According to the instructions for use, Arifon is recommended to be taken in the morning. The initial dose of indapamide for arterial hypertension is 1.25-2.5 mg per day.
Arifon retard is prescribed in the morning at a dose of 1.5 mg.
In case of ineffectiveness of therapy for a month, medications with a different principle of exposure are added to the treatment.
It is not recommended to increase the dosage of the drug because of the risk of increasing the severity of side effects.
It manifests itself as an excessive drop in blood pressure, respiratory depression, digestive system disorders, vomiting, weakness, nausea, water-electrolyte disturbances. In persons suffering cirrhosishepatic coma develops.
Symptomatic therapy, correction of water-electrolyte balance, and gastric lavage are required. A specific antidote has not been developed.
Arifon slows the excretion of lithium from the body with urine, which leads to its accumulation, nephrotoxic effect.
When using iodine-containing contrast agents in high dosages, the risk of developing pathology of the renal system increases. Before the introduction of iodine-containing contrast medications, restoration of the lost fluid is required.
Against the background of the use of Arifon, a decrease in effectiveness indirect anticoagulantsderivatives of indandion, coumarin derivatives.
The drug is able to enhance the severity of the blockade of neuromuscular transmission, which is formed when taking non-depolarizing muscle relaxants.
Glucocorticosteroids, thiazide and loop saluretics, tetracosactide, laxative medicines, amphotericin B can cause hypokalemia.
Digital Toxication recorded while taking cardiac glycosides.
Intravenous administration of erythromycin, astemizole, vincamine, trefenadine, suloprid, pentamidine, disopyramide, quinidine, sotalol, amiodarone, toretilium toretilum cause arrhythmias by the type of feasts due to synergistic effects.
Tetracosactide, glucocorticosteroids, adrenostimulants reduce the severity of the hypotensive effect of the drug, the opposite effect is recorded when prescribed baclofen.
Acute renal failure, arterial hypotension develop against the background of an additional intake of ACE inhibitors.
Antipsychotic medications, tricyclic, imipramine antidepressants increase the likelihood of developing orthostatic hypotension, increase the severity of the hypotensive effect.
Hypercreatininemia is diagnosed with cyclosporine.
Terms of sale
In a place inaccessible to children at a temperature of no more than 30 degrees Celsius.
Up to five years.
Systematic control is required over the level of magnesium, sodium, potassium ions in the blood plasma, the concentration of residual nitrogen, uric acid, blood sugar, and pH.
In patients who take laxatives, cardiac glycosides it is necessary to monitor the level of creatinine, potassium.
Closer observation is required for patients with cirrhosis.
Particular attention should be paid to patients with ascitesswelling due to risk metabolic alkalosis, which increases with hepatic encephalopathy.
The first control over the level of potassium in the blood is carried out within a week.
Diagnosis of hypercalcemia during treatment with Arifon retard may indicate undiagnosed hyperparathyroidism.
It is extremely important to regularly evaluate the dynamics of the sugar curve.
In the first days of therapy, it is possible to compensate for the lost fluid; control over the work of the renal system is required.
During doping control while taking Arifon, an unreliable result is possible.
Safety of prescribing to children, the effectiveness of the drug in people of this age group have not been established.
Arifon analogsMatches for ATX Level 4 code:ChlortalidoneClopamideRavel SRIndapamideIndap
Analogs include drugs: Vasopamide, Indap, Indapamide, Indapen, Indapres, Indiur, Ipamide, Lorvas, Ravel, Softensif, Hemopamide.
What is better indapamide or arifon?
Both drugs contain the same active substance. indapamide. It is believed that Arifon works more efficiently and creates fewer side effects, however, it costs more.
It should be remembered that both drugs have the same effect, being generic drugs.
Arifon and Arifon Retard
The Retard form is a controlled release tablet and contains 1.5 mg of active substance in one tablet instead of 2.5 mg.
The Retard form suggests a decrease in the manifestation of side effects.
According to doctors, Arifon is really effective for indications. The drug helps to control pressure, reduces swelling, works gently.
Negative opinions contain reviews of the serious side effects of the drug.
Arifon's price, where to buy
The price of Arifon in 2.5 mg tablets is 410 rubles per pack of 30 pieces.
- Online Pharmacies in Russia
- Online pharmacies in UkraineUkraine
- Online pharmacies in Kazakhstan
- Arifon Tab. p.p.o. 2.5 mg n30Servier336 rub.order
- Arifon Retard Tab. 1.5mg n30OOO Serdriks / Servier Rus326 LLC rub.order
- Arifon tablets 2.5mg №30369 rub.order
- Arifon retard tablets 1,5mg №30357 rub.order
Eurofarm * 4% discount on the promotional code medside11
- Arifon 2.5 mg n30 tablet Servier Industry Laboratories414 rub.
- Arifon retard 1.5 mg n30 tabl Serdiks, OOO408 rub.order
- Arifon retard 1.5 mg No. 30 tablets Lab.Serv e Industrial, France / Serv Industrial Ltd., Ireland / Anfarm Pharmacy. AT, Poland 99 UAH order
- Arifon Retard tablets Arifon Retard tablets 1.5mg No. 30 France, Servier Industrie 110 UAH order
- Arifon retard 1.5 mg No. 30 tablet retard Servier (France) 2 tg.