NitroglycerineRectified ethyl alcohol (ethanol).

Release form

Spray metered sublingual 0.4 mg / dose in a 10 ml polypropylene bottle with a spray nozzle in a cardboard box No. 1.

Pharmachologic effect


Pharmacodynamics and pharmacokinetics


Antianginal drug, belongs to the group of peripheral vasodilators, which affect mainly venous vessels. Mechanism of action nitroglycerin based on the ability to release nitrogen oxidebeing an endothelial relaxing factor. Based on the action of nitric oxide (increases the concentration of cyclic guanosine monophosphatase inside the cells), the penetration of calcium ions into smooth muscle cells is slowed, which causes relaxation of the smooth muscles of the vascular wall and their expansion. As a result, preload (venous return to the heart) and afterload (resistance in a large circle of blood circulation) are reduced, which reduces the oxygen demand of the heart muscle. Reducing the return of venous blood reduces filling pressure, normalizes the supply of blood to the subendocardial layers and pressure in the pulmonary circulation.

As a result of the expansion of the coronary vessels, redistribution of coronary blood flow occurs in the area with insufficient blood supply. Nitrospray (nitroglycerine) lowers the sympathetic tone of blood vessels, while the vascular component of the pain syndrome is inhibited. The drug relaxes the smooth muscle cells of the bronchi, gall bladder, urinary tract, esophagus, bile ducts, intestines and their sphincters.


The drug is rapidly absorbed from the surface of the mucous membranes, reaching a therapeutic concentration in the blood within a few minutes. Communication with blood proteins is about 60%. It is excreted in the urine.

Indications Nitrosprey

Prevention and relief of attacks with angina pectoris, acute myocardial infarction and in complex therapy acute left ventricular failure.


Arterial hypotension, shock, hemorrhagic strokevascular collapsehypertrophic cardiomyopathysharp myocardial infarction (with low filling pressure in the left ventricle), recent head injury, childhood, angle-closure glaucomatoxic pulmonary edema, pregnancylactation.

Side effects

Headacheweakness, blurred vision, dizziness, motor restlessness, nausea, vomiting, dry mouth, skin rash, arterial hypotension, dermatitis.

Nitrospray, instructions for use (Method and dosage)

Nitrospray is used sublingually in the form of an aerosol. 1 dose of aerosol contains 400 mcg nitroglycerin. At the first sign of an attack angina pectoris to stop it, the product is applied under or on the tongue for 1-2 doses of the drug (400-800 mcg) holding your breath. Shake the can before use, keep it upright when spraying.

After spraying the aerosol, it is necessary to close the mouth, but do not swallow immediately. Repeated administration of the dose should be carried out with an interval of at least 30 seconds. The drug, if necessary, is repeated, but not more than 3 doses over 15 minutes at intervals of 5 minutes.

To prevent an attack, 1 dose is administered 5-10 minutes before the expected stress or load. The maximum dosage of Nitrospray per day is 6.4 g (16 doses), single - 1.6 g (4 doses). During the period of use of the drug, you must be careful with a sharp change in body position, hot weather, physical exercises due to the risk of orthostatic reactions. During this period, it is not recommended to drink alcohol. The drug must be discontinued under the supervision of a physician and gradually.

If after injecting 3 doses for 15 minutes, the attack does not stop, the patient must be hospitalized. If the drug is accompanied by a headache, simultaneous administration is possible. acetylsalicylic acid.


Dizziness, cyanosis lips, palms, nails, fainting, shortness of breath, severe weakness or fatigue, fever, palpitations, cramps.


The hypotensive effect of Nitrospray is enhanced while taking other antihypertensive drugs, antidepressants, ethanol, and inhibitors. PDE, while the effectiveness of Nitrospray is reduced. With the simultaneous administration of Nitrospray with heparin anticoagulant effect heparin declining.

Terms of sale

OTC vacation.

Storage conditions

Away from open flame at temperatures up to 30 ° C.

Shelf life

3 years.

Analogs of Nitrospray

Matches for ATX Level 4 code:NitroglycerineEfoxMonosanNitromintPectrolIsoketErinitCardicetSustak ForteNitrosorbide

The following drugs have similar active ingredients and ATX code: Nitro, Nitroglycerine, Nitrocontin, Nitrogranulong, Nitro Mick, Nitromint, Nitromax.

Reviews about Nitrospray

There are many positive reviews about this drug. Patients note the convenience of its use and instant action. "... Nitrospray for the heart is simply irreplaceable. It relieves pressing chest pain almost instantly."

However, one should not forget that exceeding the recommended dose can cause serious complications and this drug is intended to stop attacks as an ambulance, and other drugs are needed for proper treatment.

Nitrospray price, where to buy

The price of the drug varies between 85 -110 rubles per package. The drug is always on sale in most pharmacies in Moscow.

  • Online Pharmacies in Russia
  • Online pharmacies in Kazakhstan


  • Nitrospray spray sublingual. 0.4 mg / dose 200 doses of 10 ml n1Pharmstandart-Leksredstva OAO111 rub.order

Pharmacy Dialog

  • Nitrospray (spray 1% 10ml) 106 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Nitrospray spray sublingual 0.4 mg / dose 10 ml (200 doses) Pharmstandard-Leksredstva OAO109 rub.order
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  • Nitrospray 0.4 mg / dose 200 doses 10 ml spray dosing. sublingualPharmstandart-Leksredstva OAO (Russia) 630 tenge
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Watch the video: Nitroglycerin Medication Nursing Sublingual Tablets & Oral Spray Pharmacology Review & Adminstration (February 2020).

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