In 1 tablet estradiol 2 mg and norethisterone acetate 1 mg Lactose monohydrate, corn starch, gelatin, talc, magnesium stearate, as auxiliary substances.

Release form

Tablets in a shell number 28.

Pharmachologic effect

Hormonal, anti-climacteric.

Pharmacodynamics and pharmacokinetics


Kliogest is a combined monophasic estrogen-progestogen drug intended for continuous replacement therapy. Each tablet contains the same amount. progestogen and estrogen. This combination avoids menstrual bleeding and alleviates symptoms. menopause (already in the first weeks of admission) and prevent development osteoporosis.

Synthetic 17β-estradiol identical to endogenous estradiolrelieves symptoms menopausepositively affects the mineral density of the bone, preventing its decline when oophorectomy or natural menopause. Its effect on mineral density is dose dependent.

Norethisterone also has a beneficial effect on bone tissue: eliminates or reduces pain in the bones and spine, inhibits progression osteoporosis and, to some extent, helps restore bone mineral density. In addition to treatment, 1000 mg of calcium is prescribed daily. After discontinuation of therapy, a decrease in bone mass is noted as in women who have not received treatment.

Estrogens stimulate endometrial growth and, taken alone, increase risk endometrial cancer. Combination with progestogen reduces this risk.


When taken orally estradiol quickly absorbed. Primary metabolism is carried out in the liver. The maximum concentration is determined after 6 hours. The half-life of 18 hours. It circulates as a complex with albumin and globulin. Metabolism occurs primarily in the liver and intestines before the formation of active and inactive metabolites. Estrogens excreted in the bile and urine.

Norethisterone also rapidly absorbed. Primary metabolism occurs in the liver. The maximum concentration is determined after 1 hour. The half-life of 10 hours. Contacted albumin and SHBG. Metabolites are excreted mainly in the urine.

Indications for use

  • deficiency hormone replacement therapy estrogen in women over 55 with postmenopausal women, 2 years;
  • postmenopausal prophylaxis osteoporosis in the presence of a high risk of fractures.


  • hypersensitivity;
  • established estrogen dependent tumor;
  • bleeding of unknown etiology;
  • endometrial hyperplasia;
  • thrombophlebitis deep veins;
  • pulmonary embolism;
  • myocardial infarction and angina pectoris;
  • impaired liver function;
  • mammary cancer;
  • lactose intolerance;
  • porphyria.

With caution is prescribed when leiomyoma, endometriosis, thromboembolism in the anamnesis, arterial hypertension, diabetes, cholelithiasis, Hard currency, bronchial asthma, epilepsy.

Side effects

Cliogest can cause:

  • spotting spotting;
  • intermenstrual bleeding;
  • pain in the mammary glands;
  • flatulence, stomach ache;
  • nausea, vomiting
  • skin rash, itching, alopecia;
  • headache and migraine;
  • tachycardia, arterial hypertension;
  • swelling;
  • muscle cramps;
  • increased appetite;
  • impaired glucose tolerance;
  • visual impairment.

Kliogest, instructions for use (Method and dosage)

Take orally 1 tablet 1 time per day, preferably at the same time. Skipping the drug increases the likelihood of bleeding or spotting. After the packaging is finished, the next package is immediately received.

Treatment is prescribed only if there are symptoms. postmenopausal womenthat reduce a woman’s quality of life. During treatment, medical examinations are carried out every six months, including mammogram. Treatment is canceled in case of impaired liver function, a significant increase in blood pressure, with attacks headache. If necessary, it stops at any time.

Women with amenorrhea or those who transfer from any other combination drug may start treatment any day.


An overdose is manifested by nausea and vomiting. Symptomatic treatment is carried out.


An increase in metabolism is noted when using cytochrome P450 isoenzyme inducers: phenobarbital, carbamazepine, phenytoin, rifampicin, nevirapine, rifabutin, efavirenz.

Ritonavir and nelfinavir also stimulate the metabolism of hormonal drugs.

Increased metabolism leads to a decrease in efficiency and the nature of bleeding may change. Ketoconazole increases the concentration of active substances.

Terms of sale

On prescription.

Storage conditions

Temperature up to 25 ° С.

Shelf life

4 years.


Tricequence, Divina, Active, Climonorm, Pausogest, Triaclim, Triane.

Reviews about Kliogest

Menopause - This is a hormone deficiency condition, which is corrected by hormone replacement therapy. With the uterus preserved, a mandatory condition for such treatment is a combination estrogen and progestin. Kliogest suspends development osteoporosis, and the timely onset of HRT prevents its development, as evidenced by research. Bone loss was significantly lower compared to women who did not take the drug. After 2 years of treatment, bone mineral density has increased. To ensure the best HRT result, it is necessary to conduct a long-term - 5-8 years.

Reviews about the drug are not common, due to the lack of it in the pharmacy.

"... The first months were blood-thirsty, and then everything returned to normal: the tides disappeared, she began to sleep well, irritability and tearfulness disappeared".
"... I’ve been using it for about 4 years, recently it has disappeared and they are sending me from Germany. I feel good and want to take it further so as not to doom myself to aging".

You need to know that drugs for HRT do not have a contraceptive effect.

Price, where to buy

At the moment, Kliogest is not available in the pharmacy network. You can buy Klimonorm (656-790 rubles).

  • Online Pharmacies in Russia

LuxPharma * special offer

  • Kliogest (analogue Activel) tab. n / a 28pcs 1770 rubles to order
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